Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa essential oils: chemical composition, antimicrobial and antileishmanial activity. - GreenMedInfo Summary

The resistance mechanisms of bacteria and protozoans have evidenced the need of discover new compounds with potential pharmaceutical activity against pathogenic microorganisms. Medicinal plants have been for centuries a promising alternative as sources of new drugs. The objective of this work was to evaluate the chemical composition, antimicrobial and antileishmanial activities of,, andessential oils. Chemical analysis was performed by gas chromatography-mass spectrometry. Antimicrobial activity was performed by disk diffusion and minimum inhibitory concentration (MIC) test. Antileishmanial activity was performed against antipromastigote and intracellular amastigote of. Cytotoxic and nitrite production were realized in BALB/c peritoneal macrophages. The major compounds of the essential oils were cinnamic aldehyde (46.30%) in, cis-p-menth-2-en-1-ol (33.88%) and linalyl acetate (13.90%) in, and turmerone (55.43%) in. The MIC showed significant antimicrobial activity ofessential oil against(83.3± 14.43g/mL). Antipromastigote activity showed ICvalues>500g/mL to, 308.4± 1.402g/mL to, and 405.5± 1.119g/mL toessential oil. Activity against intracellular amastigote ofshowed ICof 63.3± 1.369g/mL and cytotoxic was not observed, resulting in selectivity index higher than 15.79 to parasite.essential oil decreased nitrite production in peritoneal macrophages, but not ininfected cells. The chemical composition of the three essential oils is directly associated to its potential biological action, as the antimicrobial activity.presented a potent antileishmanial activity against promastigote and intracellular amastigote of, although this activity is not linked to nitric oxide, sinceessential oil inhibits its production.