n/a
Article Publish Status: FREE
Abstract Title:

Citronellal Exerts Its Antifungal Activity by Targeting Ergosterol Biosynthesis in.

Abstract Source:

J Fungi (Basel). 2021 May 29 ;7(6). Epub 2021 May 29. PMID: 34072578

Abstract Author(s):

Qiuli OuYang, Yangmei Liu, Okwong Reymick Oketch, Miaoling Zhang, Xingfeng Shao, Nengguo Tao

Article Affiliation:

Qiuli OuYang

Abstract:

Ergosterol (ERG) is a potential target for the development of antifungal agents against, the pathogen of green mold in citrus fruits. This study examined the mechanism by which citronellal, a typical terpenoid ofessential oil, acts on ergosterol to exhibit its antifungal activity against. We previously reported that citronellal inhibited the growth ofwith minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of 1.36 and 2.72 mg/mL, respectively. In citronellal-treated cells, the membrane integrity and ergosterol contents significantly decreased, whereas lanosterol, which serves as a precursor for ergosterol biosynthesis, massively accumulated. Addition of 150 mg/L of exogenous ergosterol decreased the inhibitory rate of citronellal, restoring the ergosterol content and hence the membrane structure to normal levels, and triggered expression of nearly all ERG genes. Based on our findings, we deduce that citronellal damages the cell membrane integrity ofby down-regulating the ERG genes responsible for conversion of lanosterol to ergosterol, the key downregulated gene being, due to the observed accumulation of ergosta-7,22-dienol.

Study Type : Plant Study
Additional Links
Pharmacological Actions : Anti-fungal effects

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.