Article Publish Status: FREE
Abstract Title:

The citrus flavanone naringenin impairs dengue virus replication in human cells.

Abstract Source:

Sci Rep. 2017 Feb 3 ;7:41864. Epub 2017 Feb 3. PMID: 28157234

Abstract Author(s):

Sandra Frabasile, Andrea Cristine Koishi, Diogo Kuczera, Guilherme Ferreira Silveira, Waldiceu Aparecido Verri, Claudia Nunes Duarte Dos Santos, Juliano Bordignon

Article Affiliation:

Sandra Frabasile


Dengue is one of the most significant health problems in tropical and sub-tropical regions throughout the world. Nearly 390 million cases are reported each year. Although a vaccine was recently approved in certain countries, an anti-dengue virus drug is still needed. Fruits and vegetables may be sources of compounds with medicinal properties, such as flavonoids. This study demonstrates the anti-dengue virus activity of the citrus flavanone naringenin, a class of flavonoid. Naringenin prevented infection with four dengue virus serotypes in Huh7.5 cells. Additionally, experiments employing subgenomic RepDV-1 and RepDV-3 replicon systems confirmed the ability of naringenin to inhibit dengue virus replication. Antiviral activity was observed even when naringenin was used to treat Huh7.5 cells 24 h after dengue virus exposure. Finally, naringenin anti-dengue virus activity was demonstrated in primary human monocytes infected with dengue virus sertoype-4, supporting the potential use of naringenin to control dengue virus replication. In conclusion, naringenin is a suitable candidate molecule for the development of specific dengue virus treatments.

Study Type : Human In Vitro
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)

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