Abstract Title:

Citrus fruit intake and bladder cancer risk: a meta-analysis of observational studies.

Abstract Source:

Int J Food Sci Nutr. 2014 Nov ;65(7):893-8. Epub 2014 Jun 16. PMID: 24932663

Abstract Author(s):

Sudong Liang, Gaofei Lv, Weikai Chen, Jianxin Jiang, Jingqun Wang

Article Affiliation:

Sudong Liang


Epidemiological studies have investigated the association between citrus fruit and bladder cancer risk; however, the results are inconsistent. To assess these issues, we conducted a meta-analysis of currently available studies. We identified relevant articles by searching the MEDLINE and EMBASE databases. We calculated the summary relative risk (RR) with 95% confidence interval (95% CI) using a random effect model. We included eight case-control studies and six cohort studies in the meta-analysis. There was a significant inverse association between citrus fruit intake and bladder cancer risk in all pooled studies (RR: 0.85; 95% CI, 0.76-0.94) and case-control studies (RR: 0.77; 95% CI, 0.64-0.92), but not in the cohort studies (RR: 0.96; 95% CI, 0.87-1.07). Our results suggest that citrus fruit intake is related to decreased bladder cancer risk. Subsequent well-designed, large prospective studies are needed to obtain better understanding of this relationship.

Study Type : Meta Analysis

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Sayer Ji
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