Abstract Title:

essential oil nanoemulsion (CLEO-NE), a safe cell-depended apoptosis inducer in human A549 lung cancer cells with anti-angiogenic activity.

Abstract Source:

J Microencapsul. 2020 May 13:1-24. Epub 2020 May 13. PMID: 32400238

Abstract Author(s):

Elnaz Yousefian Rad, Masoud Homayouni Tabrizi, Pouran Ardalan, Seyed Mohammad Reza Seyedi, Samira Yadamani, Parisa Zamani-Esmati, Nastaran Haghani Sereshkeh

Article Affiliation:

Elnaz Yousefian Rad


essential oil (CLEO) has been introduced as a strong antioxidant mixture. However, it is not efficient enough due to its hydrophobic nature. Nanoemulsions improve the drugs' bio-compatibility in aqueous conditions.The CLEO nanoemulsion (CLEO-NE) was formulated by ultrasound-based-emulsification and they were characterized. The anti-angiogenic and antioxidant activities were studied by the chicken chorioallantoic membrane (CAM) and antioxidant (ABTS and DPPH) assays, respectively. Finally, the apoptotic property of CLEO-NE on both HFF and A549 was evaluated by [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] (MTT) assay and Real time-PCR (measuring Cas-3 gene expression).The 30.2-nm CLEO-NE droplets significantly increased Cas-3 in A549 cells and decreased angiogenesis in chick embryo chorioallantoic membrane (p<0.01).In conclusion, CLEO-NE has the potential to be used as a safe cell-depended anticancer agent for human lung cancer. However, further genes and cell lines have to be studied to clarify its targeted-anticancer activity.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(6986) : AC(5304)

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