Citrus species extracts are potential candidates for dyslipidemia control. - GreenMedInfo Summary

This study aims to obtain scientific evidence on the use ofto control dyslipidemia. The surveys were carried out in 2020 and updated in March 2021, in the PubMed, Scopus, LILACS, and SciELO databases, using the following descriptors:, dyslipidemias, hypercholesterolemia, hyperlipidemias, lipoproteins, and cholesterol. The risk of bias was assessed according to the Cochrane methodology for clinical trials and ARRIVE for preclinical trials. A meta-analysis was performed using the application of R software. A total of 958 articles were identified and 26 studies demonstrating the effectiveness of thegenus in controlling dyslipidemia were selected, of which 25 were included in the meta-analysis. The effects ofproducts on dyslipidemia appear consistently robust, acting to reduce total cholesterol, LDL, and triglycerides, in addition to increasing HDL. These effects are associated with the composition of the extracts, extremely rich in antioxidant, as flavonoids, and that act on biochemical targets involved in lipogenesis and beta-oxidation. The risk of bias over all of the included studies was considered critically low to moderate. The meta-analysis demonstrated results favorable to control dyslipidemia byproducts. On the other hand, high heterogeneity values were identified, weakening the evidence presented. From this study, one can suggest thatspecies extracts are potential candidates for dyslipidemia control, but more studies are needed to increase the strength of this occurrence.