Abstract Title:

Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.

Abstract Source:

Planta Med. 2003 Feb;69(2):155-7. PMID: 12624822

Abstract Author(s):

Arunrat Sunthitikawinsakul, Ngampong Kongkathip, Boonsong Kongkathip, Sida Phonnakhu, John W Daly, Thomas F Spande, Yuth Nimit, Sasarose Rochanaruangrai


Four known coumarins, dentatin (1), nor-dentatin (2), clausenidin (3) and xanthoxyletin (5), and six known carbazole derivatives, 3-formylcarbazole (6), mukonal (7), 3-methoxycarbonylcarbazole (8), murrayanine (9), 2-hydroxy-3-formyl-7-methoxycarbazole (10) and clauszoline J (11) were isolated from Clausena excavata. Compounds 1 and 6 were first isolated from the crude chloroform extract of the rhizomes. Compounds 1, 2, 3, 6, 7, 8, 10 and 11 showed antimycobacterial activity at a minimum inhibitory concentration (MIC) of 50, 100, 200, 100, 200, 50, 100 and 100 microg/mL, respectively. O-Methylated clausenidin ( 4), prepared from 3, exhibited antimycobacterial activity at MIC 50 microg/mL. Compounds 6, 7, 8 and 10 showed antifungal activity with IC 50 values of 13.6, 29.3, 9.5 and 2.8 microg/mL, respectively. All compounds demonstrated no cytotoxicity against KB and BC-1 cell lines.

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