Abstract Title:

Antihyperglycemic and antioxidative effects of a herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a mouse model of type 2 diabetes mellitus.

Abstract Source:

Clin Exp Immunol. 2009 Apr;156(1):78-87. Epub 2009 Jan 21. PMID: 19107854

Abstract Author(s):

Judy Yuet-Wa Chan, Fung-Chun Lam, Ping-Chung Leung, Chun-Tao Che, Kwok-Pui Fung

Article Affiliation:

Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.


There is emerging evidence that the generation of reactive oxygen species (ROS), which leads to dysfunction of pancreatic beta-cells, is a major factor in the development of type 2 diabetes mellitus. Antioxidation is one of the therapeutic strategies to overwhelm the imbalance in ROS production. In this study, a herbal formulation SR10, comprising Radix Astragali, Radix Codonopsis and Cortex Lycii, was examined for its antidiabetic and antioxidative effects using the diabetic +db/+db mouse model. The results showed that SR10 was effective in decreasing the blood glucose level in chronic treatment by improving beta-cell function. The activities and expression of antioxidant enzymes, catalase and superoxide dismutase, were up-regulated when treated with SR10. Moreover, SR10 treatment did not exhibit any toxic effect to the host.

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