Codonopsis pilosula exhibits neuritogenic activity. - GreenMedInfo Summary

Abstract Title:

Codonopsis pilosula (Franch) Nannf total alkaloids potentiate neurite outgrowth induced by nerve growth factor in PC12 cells.

Abstract Source:

Neonatology. 2007;91(3):174-9. Epub 2006 Nov 29. PMID: 12956941

Abstract Author(s):

Jian-Hui Liu, Yong-Ming Bao, Ji-Jun Song, Li-Jia An

Article Affiliation:

Department of Biochemical Engineering, Dalian University of Technology, Dalian 116024, China.

Abstract:

AIM: To explore the effect of Codonopsis pilosula (Franch) Nannf total alkaloids (DSA) on differentiation induced by nerve growth factor (NGF) in PC12 cells. METHODS: After culturing PC12 cells with DSA in the presence or absence of NGF, neurite outgrowth in PC12 cells and correlated protein kinases were assayed. RESULTS: DSA alone did not exhibit neuritogenic activity, but caused a significant enhancement of NGF (2 microg/L)-induced neurite outgrowth in PC12 cells, and increased the phosphorylation of mitogen-activated protein kinase (MAPK). Furthermore, this enhancing effect was completely blocked by a specific MAPK kinase inhibitor, PD98059. CONCLUSION: DSA enhanced the NGF-induced neurite outgrowth in PC12 cells by amplifying an up-stream step of the MAPK-dependent signaling pathway.

Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Codonopsis pilosula : CK(23) : AC(5)
Diseases : Neurodegenerative Diseases : CK(8689) : AC(3890), Neurologic Disorders : CK(87) : AC(45)
Pharmacological Actions : Antiproliferative : CK(6801) : AC(6958), Neuritogenic : CK(185) : AC(101)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(965) : AC(266)

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Key Research Topics

Disease

Neurologic Disorders
Neurodegenerative Diseases

Pharmacological Actions

Neuritogenic
Antiproliferative

Substance

Codonopsis pilosula

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