Abstract Title:

A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium.

Abstract Source:

Otolaryngol Head Neck Surg. 2007 Jan;136(1):72-7. PMID: 17210337

Abstract Author(s):

Martin Khan, Johann Gross, Heidemarie Haupt, Annett Jainz, Petra Niklowitz, Hans Scherer, Frank-Peter Schmidt, Burghard F Klapp, Anett Reisshauer, Birgit Mazurek


OBJECTIVE: To determine the short-term effects of coenzyme Q10 (CoQ10) on the antioxidative status and tinnitus expression in patients with chronic tinnitus aurium. STUDY DESIGN: A 16-week prospective nonrandomized clinical trial (n = 20). Tinnitus and Short Form-36 Questionnaires (TQ/SF-36) were evaluated together with the plasma concentrations of CoQ10, malondialdehyde, and the total antioxidant status. RESULTS: The mean plasma CoQ10 concentration rose under external CoQ10 supply and remained elevated after medication stopped without overall effects on the tinnitus score. However, in a subgroup of 7 patients with low initial plasma CoQ10 concentration and significant increase in the plasma CoQ10 level, a clear decrease in the TQ score was observed. CONCLUSION: In patients with a low plasma CoQ10 concentration, CoQ10 supply may decrease the tinnitus expression. SIGNIFICANCE: This is the first study to examine the effect of CoQ10 in chronic tinnitus aurium.

Study Type : Human Study
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