Abstract Title:

Coenzyme Q10 protects neurons against neurotoxicity in hippocampal slice culture.

Abstract Source:

Neuroreport. 2011 Oct 5 ;22(14):721-6. PMID: 21849914

Abstract Author(s):

Ran Won, Kyung Hee Lee, Bae Hwan Lee

Article Affiliation:

aDepartment of Biomedical Laboratory Science bDepartment of Dental Hygiene, Division of Health Science, Dongseo University, Busan cDepartment of Physiology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.


This study investigated the neuroprotective effects of coenzyme Q10 (CoQ10) against oxidative stress induced by kainic acid (KA) in organotypic hippocampal slice culture of rats. Cultured slices were injured by exposure to 5µM of KA for 18 h and then treated with different concentrations of CoQ10. Neuronal cell death measured as propidium iodide uptake was reduced at 24 h after treatment with 1 µM of CoQ10. We also observed an increased number of surviving CA3 neurons in 0.1 and 1 µM concentrations of CoQ10-treatedgroups using cresyl violet staining. CoQ10 (0.01, 0.1, and 1 µM) treatment significantly decreased the 2',7'-dichlorofluorescein fluorescence and the expression of NQO1 in the CoQ10-treated groups was significantly lower than that in the KA-only group. These results suggest that CoQ10 may protect hippocampal neurons against oxidative stress.

Study Type : In Vitro Study

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