Abstract Title:

Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro.

Abstract Source:

Antiviral Res. 2009 Aug;83(2):186-90. Epub 2009 May 20. PMID: 19463857

Abstract Author(s):

Gui-Feng Wang, Li-Ping Shi, Yu-Dan Ren, Qun-Fang Liu, Hou-Fu Liu, Ru-Jun Zhang, Zhuang Li, Feng-Hua Zhu, Pei-Lan He, Wei Tang, Pei-Zhen Tao, Chuan Li, Wei-Min Zhao, Jian-Ping Zuo

Article Affiliation:

Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China.


Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication.

Study Type : In Vitro Study

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