Abstract Title:

Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects.

Abstract Source:

Br J Nutr. 2013 Jan 14:1-6. Epub 2013 Jan 14. PMID: 23312069

Abstract Author(s):

Tania Reyes-Izquierdo, Boris Nemzer, Cynthia Shu, Lan Huynh, Ruby Argumedo, Robert Keller, Zb Pietrzkowski

Article Affiliation:

Applied BioClinical, Inc., 16259 Laguna Canyon Road, Irvine, CA 92618, USA.


The present single-dose study was performed to assess the effect of whole coffee fruit concentrate powder (WCFC), green coffee caffeine powder (N677), grape seed extract powder (N31) and green coffee bean extract powder (N625) on blood levels of brain-derived neurotrophic factor (BDNF). Randomly assorted groups of fasted subjects consumed a single, 100 mg dose of each material. Plasma samples were collected at time zero (T 0) and at 30 min intervals afterwards, up to 120 min. A total of two control groups were included: subjects treated with silica dioxide (as placebo) or with no treatment. The collected data revealed that treatments with N31and N677 increased levels of plasma BDNF by about 31 % under these experimental conditions, whereas treatment with WCFC increased it by 143 % (n 10), compared with baseline. These results indicate that WCFC could be used for modulation of BDNF-dependent health conditions. However, larger clinicalstudies are needed to support this possibility.

Study Type : Human Study

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