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Article Publish Status: FREE
Abstract Title:

Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response.

Abstract Source:

bioRxiv. 2021 Mar 10. Epub 2021 Mar 10. PMID: 33758843

Abstract Author(s):

Long Chi Nguyen, Dongbo Yang, Vlad Nicolaescu, Thomas J Best, Takashi Ohtsuki, Shao-Nong Chen, J Brent Friesen, Nir Drayman, Adil Mohamed, Christopher Dann, Diane Silva, Haley Gula, Krysten A Jones, J Michael Millis, Bryan C Dickinson, Savaş Tay, Scott A Oakes, Guido F Pauli, David O Meltzer, Glenn Randall, Marsha Rich Rosner

Article Affiliation:

Long Chi Nguyen

Abstract:

The rapid spread of COVID-19 underscores the need for new treatments. Here we report that cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV-2 infection. CBD and its metabolite, 7-OH-CBD, but not congeneric cannabinoids, potently block SARS-CoV-2 replication in lung epithelial cells. CBD acts after cellular infection, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene transcription. CBD induces interferon expression and up-regulates its antiviral signaling pathway. A cohort of human patients previously taking CBD had significantly lower SARS-CoV-2 infection incidence of up to an order of magnitude relative to matched pairs or the general population. This study highlights CBD, and its active metabolite, 7-OH-CBD, as potential preventative agents and therapeutic treatments for SARS-CoV-2 at early stages of infection.

Study Type : Review

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