Abstract Title:

Colon targeted Curcumin microspheres laden with ascorbic acid for bioavailability enhancement.

Abstract Source:

J Microencapsul. 2018 Jul 16:1-28. Epub 2018 Jul 16. PMID: 30010458

Abstract Author(s):

Preeti G Karade, Namdeo R Jadhav

Article Affiliation:

Preeti G Karade


An objective of the present study was to prepare colon specific microspheres of Curcumin (CUR) containing Ascorbic acid (AA) for improved oral bioavailability. 3factorial design was used to optimize Chitosan microspheres (CSMS) containing CUR and AA. Subsequently, optimized CSMS were coated with Eudragit S-100, for delivery to colon. In vitro drug release, in vivo pharmacokinetics and organ distribution studies were performed in Albino wistar rats. Stabilization of CUR in alkaline pH was successfully guarded by AA to the extent 98.5-100%. Results revealed complete amorphization/molecular dispersion of CUR. Bioavailability enhancement of CUR and 90% of MS in colon at the end of 8 hours in animals, deciphered successful design of colon specific CUR microspheres. It can be concluded that AA in MS shielded the degradation of CUR. The developed double coat MS could be considered as a promising colon targeted system for CUR aiming bioavailability enhancements.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.