Abstract Title:

Combination of astaxanthin and fish oil supplementation alters antioxidant enzyme profile of dental pulp tissue.

Abstract Source:

Int Endod J. 2012 May 7. Epub 2012 May 7. PMID: 22809098

Abstract Author(s):

M F Leite, A M Lima, R Otton

Article Affiliation:

Universidade Cruzeiro do Sul, São Paulo, Brazil.


AIM: To evaluate the effect of administration of astaxanthin (ASTA) and fish oil (FO) on enzymatic antioxidant parameters of dental pulp tissue from healthy rats. METHODOLOGY: Thirty-two healthy Wistar rats were divided into four groups: untreated control, ASTA-treated (1 mg kg(-1) body weight), FO-treated (10 mg eicosapentaenoic acid per kg BW and 7 mg docosahexaenoic acid per kg BW) and FO plus ASTA-treated. A prophylactic dose was administered in each group daily by gavage, 5 days a week, for 45 days. After treatment, the rats were killed and all incisor dental pulps were removed. Superoxide dismutase (SOD), catalase, glutathione (GSH) peroxidase and reductase activities were determined. Data were compared by anova and the Tukey's post-test ( P  < 0.05). RESULTS: Treatment with FO, ASTA and FO plus ASTA caused a reduction in SOD and GSH reductase activities in dental pulp tissue compared to untreated control rats ( P  < 0.05). ASTA partially stimulated catalase activity. CONCLUSIONS: The preventive administration of ASTA and FO changed the enzymatic antioxidant system of dental pulp tissue, possibly by controlling oxidative stress.

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.