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Abstract Title:

Combinational exposure to Bisphenol A and a high-fat diet causes trans-generational Malfunction of the female reproductive system in mice.

Abstract Source:

Mol Cell Endocrinol. 2021 Nov 13 ;541:111507. Epub 2021 Nov 13. PMID: 34785282

Abstract Author(s):

Rongfeng Huang, Jiayu Li, Maolin Liao, Li Ma, Irakoze Laurent, Xiaojing Lin, Yunqi Zhang, Rufei Gao, Yubin Ding, Xiaoqiu Xiao

Article Affiliation:

Rongfeng Huang

Abstract:

Bisphenol A (BPA) is a common endocrine disruptor and a high-fat diet (HFD) also affects fertility. However, little is known about the long-term consequences of simultaneous exposure to BPA and a HFD on reproductive health. Herein, we assessed the effects of maternal exposure to BPA in combination with a HFD on reproductive function in subsequent generations of female mice and evaluated its effects on the hypothalamic-pituitary-gonadal axis. We found that the combination of maternal exposure to BPA and a HFD led to increased urine BPA levels, precocious puberty, altered estrous cyclicity, decreased follicle numbers, and altered hypothalamic Kiss1 methylation status in F1 and F2 mice. Therefore, we demonstrated that maternal exposure to BPA in combination with a HFD exerts a trans-generational effect on female reproduction.

Study Type : Animal Study

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Sayer Ji
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