Article Publish Status: FREE
Abstract Title:

Sodium Bicarbonate-Ascorbic Acid Combination for Prevention of Contrast-Induced Nephropathy in Chronic Kidney Disease Patients Undergoing Catheterization.

Abstract Source:

Circ J. 2017 Jan 25 ;81(2):235-240. Epub 2016 Dec 22. PMID: 28003574

Abstract Author(s):

Kota Komiyama, Takashi Ashikaga, Dai Inagaki, Tomonori Miyabe, Marina Arai, Kiyotaka Yoshida, Satoshi Miyazawa, Akihiro Nakada, Iwanari Kawamura, Shinichiro Masuda, Sho Nagamine, Rintaro Hojo, Yuya Aoyama, Takaaki Tsuchiyama, Seiji Fukamizu, Takashi Shibui, Harumizu Sakurada

Article Affiliation:

Kota Komiyama


BACKGROUND: Sodium bicarbonate and ascorbic acid have been proposed to prevent contrast-induced nephropathy (CIN). The present study evaluated the effect of their combined use on CIN incidence.Methods and Results:We prospectively enrolled 429 patients with chronic kidney disease (CKD: baseline estimated glomerular filtration rate<60 mL/min/1.73 m(2)) prior to elective coronary catheterization. CIN was defined as absolute (≥0.5 mg/dL) or relative (≥25%) increase in serum creatinine within 72 h. In the saline hydration (n=218) and combined sodium bicarbonate+ascorbic acid (n=211) groups, a total of 1,500-2,500 mL 0.9% saline was given before and after the procedure. In addition, the combination group received 20 mEq sodium bicarbonate and 3 g ascorbic acid i.v. before the procedure, followed by 2 g ascorbic acid after the procedure and a further 2 g after 12 h. There were no significant differences between the basic characteristics and contrast volume in the 2 groups. CIN occurred in 19 patients (8.7%) in thesaline group, and in 6 patients (2.8%) in the combined treatment group (P=0.008).

CONCLUSIONS: Combined sodium bicarbonate and ascorbic acid could prevent CIN following catheterization in CKD patients.

Study Type : Human Study

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