Abstract Title:

Quercetin potentiates the antitumor activity of rituximab in diffuse large B-cell lymphoma by inhibiting STAT3 pathway.

Abstract Source:

Cell Biochem Biophys. 2014 Nov ;70(2):1357-62. PMID: 24902540

Abstract Author(s):

Xin Li, Xinhua Wang, Mingzhi Zhang, Aimin Li, Zhenchang Sun, Qi Yu

Article Affiliation:

Xin Li


STAT3 pathway plays an important role in the growth of diffuse large B-cell lymphoma (DLBCL) cells. Here we investigated the antitumor activity of Quercetin, a flavonoid compound, in combination with rituximab in DLBCL cell lines in vitro. We found that Quercetin synergistically enhanced rituximab-induced growth inhibition and apoptosis in DLBCL cell lines. Moreover, we found Quercetin exerted inhibitory activity against STAT3 pathway and downregulated the expression of survival genes. These results suggest that combining the Quercetin with rituximab may present an attractive and potentially effective way for the treatment of DLBCL.

Study Type : In Vitro Study

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