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Abstract Title:

The anti-osteoporosis and antioxidant activities of chemical constituents from Chrysanthemum indicum flowers.

Abstract Source:

Phytother Res. 2015 Apr ;29(4):540-8. Epub 2015 Jan 19. PMID: 25597611

Abstract Author(s):

Bui Thi Thuy Luyen, Bui Huu Tai, Nguyen Phuong Thao, Young Mi Lee, Sang Hyun Lee, Hae Dong Jang, Young Ho Kim

Article Affiliation:

Bui Thi Thuy Luyen

Abstract:

Two new compounds, chrysinoneside A (1) and (-)-trans-chrysanthenol-6-O-β-D-glucopyranoside (2), along with 17 known compounds (3-19) were isolated from Chrysanthemum indicum flowers. The total phenolic and flavonoid contents of various fractions were determined. The EtOAC fraction had the highest total phenolic content (525.84 ± 23.51 mg GAE/g DR) and the totalflavonoid content (63.49 ± 3.32 mg QE/g DR). The EtOAc and water fractions showed the greatest peroxyl radical-scavenging capacity and the ability to reduce Cu(I) ions, with ORAC and CUPRAC values ranging from 24.00 ± 0.44 to 28.06 ± 1.35 and 16.90 ± 0.51 to 49.77 ± 0.97 μM, respectively. Compounds 5-11, 18, and 19 displayed strong effects in both peroxyl radical-scavenging and reducing capacity assays at a concentration of 10 μM. The anti-osteoporosis activity of these compounds was also evaluated. Compounds 10, 13, and 19 exhibited the most potent tartrate-resistant acid phosphatase activity in receptor activator of nuclear factor-κB ligand-induced osteoclastic RAW 264.7 cells with values of 105.95 ± 1.18, 110.32 ± 3.95, and 112.58 ± 6.42%, respectively.

Study Type : In Vitro Study

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