Abstract Title:

In vitro anti-influenza viral activities of constituents from Caesalpinia sappan.

Abstract Source:

Planta Med. 2009 Mar;75(4):337-9. Epub 2009 Jan 15. PMID: 19148862

Abstract Author(s):

Ai-Lin Liu, Shi-Hui Shu, Hai-Lin Qin, Simon Ming Yuen Lee, Yi-Tao Wang, Guan-Hua Du


Six constituents with neuraminidase (NA) inhibitory activity, namely brazilein, brazilin, protosappanin A, 3-deoxysappanchalcone, sappanchalcone and rhamnetin, were isolated from the hearthwood of Caesalpinia sappan (Leguminosae). Their in vitro anti-influenza virus activities were evaluated with the cytopathic effect (CPE) reduction method. The results showed that 3-deoxysappanchalcone and sappanchalcone exhibited the highest activity against influenza virus (H3N2) with IC50 values of 1.06 and 2.06 microg/mL, respectively, in comparison to the positive control oseltamivir acid and ribavirin with IC50 values of 0.065 and 9.17 microg/mL, respectively.

Study Type : In Vitro Study

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