Article Publish Status: FREE
Abstract Title:

Neuraminidase Inhibitors from the Fermentation Broth of Phellinus linteus.

Abstract Source:

Mycobiology. 2014 Jun ;42(2):189-92. Epub 2014 Jun 30. PMID: 25071390

Abstract Author(s):

Byung Soon Hwang, Myeong-Seok Lee, Seung Woong Lee, In-Kyoung Lee, Geon-Sik Seo, Hwa Jung Choi, Bong-Sik Yun

Article Affiliation:

Byung Soon Hwang


During a search for neuraminidase inhibitors derived from medicinal fungi, we found that the fermentation broth of Phellinus linteus exhibited potent neuraminidase inhibitory activity. Through bioassay-guided fractionation, two active compounds were purified from the ethyl acetate-soluble portion of the fermentation broth of P. linteus. These structures were identified as inotilone (1) and 4-(3,4-dihydroxyphenyl)-3-buten-2-one (2) by spectroscopic methods. Compounds 1 and 2 inhibited H1N1 neuraminidase activity with IC50 values of 29.1 and 125.6µM, respectively, in a dose-dependent manner. They also exhibited an antiviral effect in a viral cytopathic effect reduction assay using MDCK cells. These results suggest that compounds 1 and 2 from the culture broth of P. linteus would be good candidates for the prevention and therapeutic strategies towards viral infections.

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