Abstract Title:

Preventive effect of sesquiterpenes from bay leaf on blood ethanol elevation in ethanol-loaded rat: structure requirement and suppression of gastric emptying.

Abstract Source:

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2647-52. PMID: 10509909

Abstract Author(s):

H Matsuda, H Shimoda, T Uemura, M Yoshikawa

Article Affiliation:

Kyoto Pharmaceutical University, Japan.


The methanolic extract from the leaves of Laurus nobilis (bay leaf, laurel) potently inhibited the elevation of blood ethanol level in ethanol-loaded rat. Through bioassay-guided separation, costunolide, dehydrocostus lactone, and santamarine were isolated as the active constituents and the alpha-methylene-gamma-butyrolactone structure was found to be essential for the preventive effect on ethanol absorption. In addition, the retardation of gastric emptying seemed to be partially involved in the preventive effects.

Study Type : Animal Study

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