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Article Publish Status: FREE
Abstract Title:

Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines.

Abstract Source:

Cell Discov. 2021 Oct 26 ;7(1):99. Epub 2021 Oct 26. PMID: 34697287

Abstract Author(s):

Jiping Liu, Junbang Wang, Jinfang Xu, Han Xia, Yue Wang, Chunxue Zhang, Wei Chen, Huina Zhang, Qi Liu, Rong Zhu, Yiqi Shi, Zihao Shen, Zhonggang Xing, Wenxia Gao, Liqiang Zhou, Jinliang Shao, Jiayu Shi, Xuejiao Yang, Yaxuan Deng, Li Wu, Quan Lin, Changhong Zheng, Wenmin Zhu, Congrong Wang, Yi E Sun, Zhongmin Liu

Article Affiliation:

Jiping Liu

Abstract:

Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection. Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) before and 28 days after the first inoculation also revealed consistent alterations in gene expression of many different immune cell types. Reduction of CD8T cells and increase in classic monocyte contents were exemplary. Moreover, scRNA-seq revealed increased NF-κB signaling and reduced type I interferon responses, which were confirmed by biological assays and also had been reported to occur after SARS-CoV-2 infection with aggravating symptoms. Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders.

Study Type : Human Study

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Sayer Ji
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