Abstract Title:

A constituent of Pterocarpus marsupium, (-)-epicatechin, as a potential antidiabetic agent.

Abstract Source:

J Nat Prod. 1983 Mar-Apr;46(2):232-4. PMID: 6875579

Abstract Author(s):

E W Sheehan, M A Zemaitis, D J Slatkin, P L Schiff


An active constituent of Pterocarpus marsupium, (-)-epicatechin (1), has been reported to reverse hyperglycemia in alloxan diabetic rats when given before or within 24 hr after the dose of alloxan. However, when doses of (-)-epicatechin (30 mg/kg, i.p., twice daily for 3 days) are begun 92 hr after alloxan, there is no significant difference in blood glucose levels between control and (-)-epicatechin treated rats. These data suggest that, although (-)-epicatechin may protect against alloxan toxicity under certain conditions, the usefulness of (-)-epicatechin appears minimal in the treatment of already established diabetic states.

Study Type : Animal Study

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