The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
Clin Endocrinol (Oxf). 2016 Dec 2. Epub 2016 Dec 2. PMID: 27911471
BACKGROUND: Data on the effects of coenzyme Q10 (CoQ10) supplementation on metabolic profiles among subjects with polycystic ovary syndrome (PCOS) are scarce.
OBJECTIVE: This study was done to evaluate the effects of CoQ10 supplementation on glucose metabolism and lipid profiles in subjects with PCOS.
DESIGN, PATIENTS AND MEASUREMENTS: This randomized double-blind, placebo-controlled trial was conducted on 60 women diagnosed with PCOS. Subjects were randomly assigned into two groups to intake either 100 mg CoQ10 supplements (N=30) or placebo (N=30) per day for 12 weeks. Markers of insulin metabolism and lipid profiles were assessed at first and 12 weeks after the intervention.
RESULTS: After 12 weeks of intervention, compared to the placebo, subjects who CoQ10 supplements had significantly decreased fasting plasma glucose (-0.24±0.51 vs. +0.01±0.44 mmol/L, P=0.04), serum insulin concentrations (-7.8±14.4 vs. +6.0±15.0 pmol/L, P<0.001), the homeostasis model of assessment-estimated insulin resistance (-0.3±0.6 vs. +0.2±0.6, P=0.001), the homeostasis model of assessment-estimated B cell function (-5.4±9.5 vs. +4.5±9.9, P<0.001) and increased the quantitative insulin sensitivity check index (+0.006±0.009 vs. -0.006±0.01, P<0.001). In addition, changes in serum total- (-0.10±0.48 vs. +0.19±0.50 mmol/L, P=0.02) and LDL-cholesterol concentrations (-0.15±0.40 vs. +0.14±0.49 mmol/L, P=0.01) in supplemented women were significantly different from those of women in the placebo group. When we adjusted the analysis for baseline values of biochemical parameters, age and baseline BMI, serum LDL-cholesterol (P=0.05) became non-significant, other findings did not alter.
CONCLUSIONS: Overall, CoQ10 supplementation for 12 weeks among subjects with PCOS had beneficial effects on glucose metabolism, serum total- and LDL-cholesterol levels. This article is protected by copyright. All rights reserved.