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Article Publish Status: FREE
Abstract Title:

Cordycepin enhances radiosensitivity to induce apoptosis through cell cycle arrest, caspase pathway and ER stress in MA-10 mouse Leydig tumor cells.

Abstract Source:

Am J Cancer Res. 2022 ;12(8):3601-3624. Epub 2022 Aug 15. PMID: 36119830

Abstract Author(s):

Yi-Ping Lee, Wei-Ru Huang, Wun-Syuan Wu, Yuan-Hua Wu, Sheng-Yow Ho, Ying-Jan Wang, Bu-Miin Huang

Article Affiliation:

Yi-Ping Lee

Abstract:

Radiotherapy is a localized treatment commonly used in various types of cancer. However, major limitation of radiotherapy is the development of resistance of tumor cells to radiosensitivity. Cordycepin, a predominant functional component of the, is considered to use in treating tumor cells. In the present study, we investigated the anticancer effect of the combination of radiation and cordycepin in the treatment of Leydig tumor cells. Results showed that the combination treatment has a synergistic effect significantly suppress cell viability and enhance the radiosensitivity in MA-10 mouse Leydig tumor cells. The combination treatment induced MA-10 cell apoptosis through increasing levels of cleaved caspase-3/-8/-9, poly ADP-ribose polymerase (PARP), and cytochrome c and decreasing levels of B-cell lymphoma 2 (Bcl-2). In addition, prolonged sub-G1 and G2/M arrest accompany with cell cycle-related protein regulation was observed in cells that received the combination treatment. The endoplasmic reticulum (ER) stress-related protein expressions were regulated after MA-10 cells treating with a combination of 100μM cordycepin and 4 Gy radiation. Furthermore, the combination treatment also decreased the Leydig tumor mass by increasing cell apoptosis in tumor-bearing mice. In conclusion, cordycepin enhances radiosensitivity to induce mouse Leydig tumor cells toward apoptosisand. This study will provide a scientific basis for the development of therapeutic regimen of testicular cancer.

Study Type : Animal Study, In Vitro Study

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