Cordycepin inhibited the retinoblastoma cell proliferation, migration and invasion as well as lung metastasis. - GreenMedInfo Summary
Cordycepin inhibited the retinoblastoma cell proliferation, migration and invasion as well as lung metastasis via modulating c-Myc/cyclin D1 pathway.
Chem Biol Drug Des. 2022 Sep 30. Epub 2022 Sep 30. PMID: 36178076
Yao Min
This study aims to investigate cordycepin's effects on the proliferation, migration and invasion of retinoblastoma (RB) cells and its regulatory mechanism. In this study, it was found that cordycepin inhibited RB cell proliferation, migration and invasion in vitro, and pulmonary metastasis in vivo. c-Myc was a downstream target of cordycepin, and cordycepin significantly suppressed c-Myc expression, and c-Myc overexpression markedly counteracted the impacts of cordycepin on RB cell proliferation, migration and invasion. c-Myc was positively correlated with the cell cycle pathway. Cordycepin restrained cyclin D1 expression, and c-Myc overexpression rescued this effect. In conclusion, cordycepin targets the c-Myc/cyclin D1 pathway, thereby suppressing the malignant biological behaviors of RB cells.