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Article Publish Status: FREE
Abstract Title:

Reduces Oxidative Stress and Regulates Immune T Cells to Inhibit Metastatic Melanoma Invasion.

Abstract Source:

Antioxidants (Basel). 2022 Jul 30 ;11(8). Epub 2022 Jul 30. PMID: 36009221

Abstract Author(s):

Yuan-Hong Lan, Yun-Sheng Lu, Ju-Yu Wu, Hsu-Tung Lee, Penjit Srinophakun, Gizem Naz Canko, Chien-Chih Chiu, Hui-Min David Wang

Article Affiliation:

Yuan-Hong Lan

Abstract:

In this study, the water extract of(Linn.) Link (CM) was used as a functional material to investigate the inhibitory mechanisms on B16F10 and lung metastatic melanoma (LMM) cells. Reducing power, chelating ability, and 2,2-diphenyl-2-picrylhydrazyl (DPPH) assays were applied for antioxidative capacities, and we obtained positive results from the proper concentrations of CM. To examine the ability of CM in melanoma proliferation inhibition and to substantiate the previous outcomes, three cellular experiments were performed via (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, MTT, a tetrazole) assay, cell migration, and invasion evaluation. The addition of CM to the incubation medium increased the number of CD8+ T cells significantly, which improved the immunogenicity. This study showed that CM exhibits various biological capabilities, including antioxidation, anti-tumor, tumor invasion suppression, and T cytotoxic cell activity promotion.

Study Type : In Vitro Study

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