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Article Publish Status: FREE
Abstract Title:

Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander Seeds.

Abstract Source:

Molecules. 2021 Jan 18 ;26(2). Epub 2021 Jan 18. PMID: 33477662

Abstract Author(s):

Hamza Mechchate, Imane Es-Safi, Amal Amaghnouje, Smahane Boukhira, Amal A Alotaibi, Mohammed Al-Zharani, Fahd A Nasr, Omar M Noman, Raffaele Conte, El Hamsas El Youbi Amal, Hicham Bekkari, Dalila Bousta

Article Affiliation:

Hamza Mechchate

Abstract:

L. seeds are traditionally used to treat diabetes and its complications (inflammation and formation of reactive oxygen species) around the world. The present study investigates the antidiabetic, anti-inflammatory, and antioxidant effects of the polyphenol fraction ofseeds (PCS). Diabetic mice were orally administered with PCS (25 and 50 mg/kg b.w.) for 28 days. Oral glucose tolerance (OGTT) was also evaluated along with the anti-inflammatory effect, assessed by measuring paw edema development induced with carrageenan in Wistar rat and the antioxidant activity assessed using two tests (β-carotene discoloration and DPPH). Treatment of diabetic mice with PCS for four weeks managed their high fasting blood glucose levels, improved their overall health, also revealed an excellent antihyperlipidemic activity. The OGTT result showed a potent antihyperglycemic activity, and following the anti-inflammatory and antioxidant effects, the PCS exhibited a perfect activity. LC-MS/MS result revealed the presence of 9 polyphenols. This modest work indicates that the PCS have an important antidiabetic, antihyperglycemic, antihyperlipidemic, anti-inflammatory, and antioxidant effect that canbe well established treatment of diabetes and its complications.

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