Abstract Title:

The correlation between intestinal dysbiosis and the development of ankylosing spondylitis.

Abstract Source:

Microb Pathog. 2019 Jul ;132:188-192. Epub 2019 Apr 27. PMID: 31039390

Abstract Author(s):

Lilong Zhang, Yuqi Hu, Yao Xu, Pengfei Li, Hong Ma, Xia Li, Ming Li

Article Affiliation:

Lilong Zhang


The pathogenesis and development of ankylosing spondylitis (AS) is concealed and complicated. In recent years, alterations in gut microbiota of AS patients have been largely investigated, although the underlying mechanisms remain unclear. This article reviews the recent studies on changes of gut microbiota in AS patients, and discusses the possible correlation between intestinal dysbiosis and AS development from aspects including genetic factor HLA-B27, mucosal immune responses and the depression accompanying AS.

Study Type : Review

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