Abstract Title:

Attenuation of carbon tetrachloride-induced hepatotoxicity by cow urine distillate in rats.

Abstract Source:

Biomed Environ Sci. 2009 Aug;22(4):345-7. PMID: 19950531

Abstract Author(s):

M P Gururaja, A B Joshi, Himanshu Joshi, D Sathyanarayana, E V S Subrahmanyam, K S Chandrashekhar

Article Affiliation:

Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Paneer Deralakatte Mangalore-574160, India. [email protected]


OBJECTIVE: To study the carbon tetrachloride-induced hepatoprotective activity in cow urine. METHODS: Effect of cow urine distillate on liver function was studied in vivo in rats intoxicated with carbon tetrachloride (CCl4). Hepatotoxicity was induced by a 1:1 (v/v) mixture of CCl4 in olive oil (5 mL/kg i.p). Protective effect of cow urine distillate (in three dose levels) and standard drug Silymarin (100 mg/kg, p.o) on liver function were studied in intoxicated rats. Parameters in the study included liver function tests and histological observations. RESULTS: The cow urine distillate decreased the levels of SGOT, SGPT, ALP, GGT, and total bilirubin in a dose-dependent manner (P<0.05) as sylimarin. CONCLUSION: The observed protective effects of cow urine distillate on liver function might be due to the presence of antioxidants in cow urine.

Study Type : Animal Study

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Sayer Ji
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