Abstract Title:

Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease.

Abstract Source:

Chin J Nat Med. 2016 Jun ;14(6):427-33. PMID: 27473960

Abstract Author(s):

Hong Guo, Yu-Qing Dong, Bo-Ping Ye

Article Affiliation:

Hong Guo


Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviatingβ-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of Aβ toxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on Aβ toxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.

Study Type : Animal Study

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