Article Publish Status: FREE
Abstract Title:

Suppresses LPS-Induced Oxidative Stress during Inflammatory Response in Human Keratinocytes by Regulating the MAPKs/AP-1, NFκB, and NFAT Signaling Pathways.

Abstract Source:

Molecules. 2021 Feb 6 ;26(4). Epub 2021 Feb 6. PMID: 33562140

Abstract Author(s):

Quynh T N Nguyen, Minzhe Fang, Mengyang Zhang, Nhung Quynh Do, Minseon Kim, Sheng Dao Zheng, Eunson Hwang, Tae Hoo Yi

Article Affiliation:

Quynh T N Nguyen


belongs to the family Rosaceae, which has been widely investigated for pharmacological effects on the circulatory and digestive systems. However, there is limited understanding about its anti-oxidative stress and anti-inflammatory effects on skin. In this study, 70% ethanolberry extract (CLE) was investigated on lipopolysaccharide (LPS)-stimulated keratinocytes. The LPS-induced overproduction of reactive oxygen species (ROS) was suppressed by the treatment with CLE. In response to ROS induction, the overexpression of inflammatory regulating signaling molecules including mitogen-activated protein kinases (MAPK)/activator protein-1 (AP-1), nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB), and nuclear factor of activated T-cells (NFAT) were reduced in CLE-treated human keratinocytes. Consequently, CLE significantly suppressed the mRNA levels of pro-inflammatory chemokines and interleukins in LPS-stimulated cells. Our results indicated that CLE has protective effects against LPS-induced injury in an in vitro model and is a potential alternative agent for inflammatory treatment.

Study Type : In Vitro Study

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Sayer Ji
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