Article Publish Status: FREE
Abstract Title:

Bunge Inhibits RANKL-Induced Osteoclast Differentiation in RAW 264.7 Cells and Prevents Bone Loss in an Ovariectomized Rat Model.

Abstract Source:

Evid Based Complement Alternat Med. 2021 ;2021:5521562. Epub 2021 Mar 27. PMID: 33859705

Abstract Author(s):

Minsun Kim, MinBeom Kim, Jae-Hyun Kim, SooYeon Hong, Dong Hee Kim, Sangwoo Kim, Eun-Young Kim, Hyuk-Sang Jung, Youngjoo Sohn

Article Affiliation:

Minsun Kim


Osteoporosis is characterized by a decrease in bone microarchitecture with an increased risk of fracture. Long-term use of primary treatments, such as bisphosphonates and selective estrogen receptor modulators, results in various side effects. Therefore, it is necessary to develop alternative therapeutics derived from natural products.Bunge (CPB) is a dried fruit used to treat diet-induced indigestion, loss of appetite, and diarrhea. However, research into the effects of CPB on osteoclast differentiation and osteoporosis is still limited.experiments were conducted to examine the effects of CPB on RANKL-induced osteoclast differentiation in RAW 264.7 cells. Moreover, we investigated the effects of CPB on bone loss in the femoral head in an ovariectomized rat model using microcomputed tomography., tartrate-resistant acid phosphatase (TRAP) staining results showed the number of TRAP-positive cells, and TRAP activity significantly decreased following CPB treatment. CPB also significantly decreased pit formation. Furthermore, CPB inhibited osteoclast differentiation by suppressing NFATc1, and c-Fos expression. Moreover, CPB treatment inhibited osteoclast-related genes, such as, and., bone mineral density and structure model index were improved by administration of CPB. In conclusion, CPB prevented osteoclast differentiationand prevented bone lossTherefore, CPB could be a potential alternative medicine for bone diseases, such as osteoporosis.

Study Type : Animal Study, In Vitro Study
Additional Links
Pharmacological Actions : Osteoprotective : CK(971) : AC(351)

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