Abstract Title:

Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG.

Abstract Source:

Neurology. 2006 Jan 24;66(2):250-2. PMID: 16434666

Abstract Author(s):

S M Hersch, S Gevorkian, K Marder, C Moskowitz, A Feigin, M Cox, P Como, C Zimmerman, M Lin, L Zhang, A M Ulug, M F Beal, W Matson, M Bogdanov, E Ebbel, A Zaleta, Y Kaneko, B Jenkins, N Hevelone, H Zhang, H Yu, D Schoenfeld, R Ferrante, H D Rosas

Abstract:

In a randomized, double-blind, placebo-controlled study in 64 subjects with Huntington disease (HD), 8 g/day of creatine administered for 16 weeks was well tolerated and safe. Serum and brain creatine concentrations increased in the creatine-treated group and returned to baseline after washout. Serum 8-hydroxy-2'-deoxyguanosine (8OH2'dG) levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by creatine treatment.

Study Type : Human Study

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