Article Publish Status: FREE
Abstract Title:

L. Extract Containing Polyphenols Modulates Oxidative Stress and Inflammatory Response against Anti-Tuberculosis Drugs-Induced Liver Injury.

Abstract Source:

Plants (Basel). 2020 Jan 30 ;9(2). Epub 2020 Jan 30. PMID: 32019201

Abstract Author(s):

Adil Farooq Wali, Jayachithra Ramakrishna Pillai, Yusra Al Dhaheri, Muneeb U Rehman, Ambreen Shoaib, Omar Sarheed, Salma Jabnoun, Maryam Razmpoor, Saiema Rasool, Bilal Ahmad Paray, Parvaiz Ahmad

Article Affiliation:

Adil Farooq Wali


The purpose of this study is to analyze the polyphenolic rich extract ofL. petals (CSP) in modulating liver oxidative stress and inflammatory response status against rifampicin isoniazid (INH-RIF) drug-induced liver injury. The INH-RIF was administered for 14 days with varying doses in Wistar rats, while silymarin was administered as standard dose. We report the defensive impacts of CSP against INH-RIF induced liver oxidative stress and proinflammatory cytokine. The CSP treatment at both doses significantly controlled all modulating biochemical hepatic injury indicators and resulted in the attenuation of arbitral INH-RIF damage. The components present in CSP identified by LC-ESI-Q-TOF-MS were found to be flavonoids and fatty acids. It can be inferred that CSP possesses a hepatoprotective capacity against INH-RIF-mediated hepatic injury, which may prove to be a medically beneficial natural product for the management of drug-induced liver injury.

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