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Article Publish Status: FREE
Abstract Title:

Crude Polysaccharide Extracted FromLeaves Prevents Obesity in Association With Modulating Gut Microbiota in High-Fat Diet-Fed Mice.

Abstract Source:

Front Nutr. 2022 ;9:861588. Epub 2022 Apr 25. PMID: 35548566

Abstract Author(s):

Lingfei Li, Li Ma, Yanlong Wen, Jing Xie, Liang Yan, Aibing Ji, Yin Zeng, Yang Tian, Jun Sheng

Article Affiliation:

Lingfei Li

Abstract:

is a commonly used plant with high nutritional and medicinal values.leaves are considered a new food resource in China. However, the biological activities ofpolysaccharides (MOP) in regulating gut microbiota and alleviating obesity remain obscure. In the present study, we prepared the MOP and evaluated its effects on obesity and gut microbiota in high-fat diet (HFD)-induced C57BL/6J mice. The experimental mice were supplemented with a normal chow diet (NCD group), a high-fat diet (HFD group), and HFD along with MOP at a different dose of 100, 200, and 400 mg/kg/d, respectively. Physiological, histological, biochemical parameters, genes related to lipid metabolism, and gut microbiota composition were compared among five experimental groups. The results showed that MOP supplementation effectively prevented weight gain and lipid accumulation induced by HFD, ameliorated blood lipid levels and insulin resistance, alleviated the secretion of pro-inflammatory cytokines, and regulated the expression of genes related to lipid metabolism and bile acid metabolism. In addition, MOP positively reshaped the gut microbiota composition, significantly increasing the abundance of, norank_f_Ruminococcaceae, and, while decreasing the relative abundance of, and, which are closely associated with obesity. These results demonstrated that MOP supplementation has a protective effect against HFD-induced obesity in mice, which was associated with reshaping the gut microbiota. To the best of our knowledge, this is the first report on the potential of MOP to prevent obesity and modulating gut microbiota, which suggests that MOP can be used as a potential prebiotic.

Study Type : Animal Study

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