Abstract Title:

Mechanisms of copper toxicity in Saccharomyces cerevisiae determined by microarray analysis.

Abstract Source:

Environ Toxicol. 2008 Oct;23(5):599-606. PMID: 18528910

Abstract Author(s):

Daisuke Yasokawa, Satomi Murata, Emiko Kitagawa, Yumiko Iwahashi, Ryoji Nakagawa, Tazusa Hashido, Hitoshi Iwahashi

Article Affiliation:

Hokkaido Food Processing Research Center, 589-4 Bunkyodai Midorimachi, Ebetsu, Hokkaido 0690836, Japan. [email protected]


The effect of the heavy metal copper on the expression of a wide spectrum of genes was analyzed by using a DNA microarray. The gene expression profile of baker's yeast Saccharomyces cerevisiae grown in a medium containing a sublethal concentration of cupric sulfate was compared with that of yeast grown in a normal medium. Among approximately 6000 yeast ORFs, 143 ORFs were induced more than twofold to resist copper toxicity after exposure to copper. Copper metallothionein CUP1-1 and CUP1-2 were induced more than 20-fold. Some genes related to sulfur metabolism and oxidative stress response were also up-regulated. This DNA microarray analysis identified several molecular targets of copper toxicity.

Study Type : In Vitro Study
Additional Links
Problem Substances : Cupric Sulfate : CK(54) : AC(0)

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