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Article Publish Status: FREE
Abstract Title:

Curcumanes E and F, two rare sesquiterpenoids with a dicyclo[3.3.1]nonane moiety, fromand their vasorelaxant activities.

Abstract Source:

Front Chem. 2022 ;10:995950. Epub 2022 Sep 2. PMID: 36118322

Abstract Author(s):

Juan Liu, Ming-Ming Qiao, Cheng Peng, Hong-Zhen Shu, Chun-Wang Meng, Fei Liu, Liang Xiong

Article Affiliation:

Juan Liu

Abstract:

Two new sesquiterpenoids, curcumanes E () and F (), were isolated from the rhizome of, and their structures and absolute configurations were examined using extensive spectroscopic analyses and ECD calculations. Interestingly, compoundsandare diastereoisomers possessing a rare sesquiterpenoid skeleton that has been reported only once before. Both curcumanes E and F exhibit significant vasorelaxant effects against KCl-induced contraction of rat aortic rings, with ECvalues of 5.10± 0.79 and 5.58 ± 1.77 μM, respectively. These findings enrich the data concerning this rare type of sesquiterpenoids and further indicate that these rare sesquiterpenoids can effectively reduce blood pressure.

Study Type : Animal Study

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