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Abstract Title:

Curcumin and cardiovascular diseases: Focus on cellular targets and cascades.

Abstract Source:

Biomed Pharmacother. 2021 Jan 12 ;136:111214. Epub 2021 Jan 12. PMID: 33450488

Abstract Author(s):

Ali Mohammad Pourbagher-Shahri, Tahereh Farkhondeh, Milad Ashrafizadeh, Marjan Talebi, Saeed Samargahndian

Article Affiliation:

Ali Mohammad Pourbagher-Shahri

Abstract:

Cardiovascular diseases (CVDs) are one of the leading causes of the most considerable mortality globally, and it has been tried to find the molecular mechanisms and design new drugs that triggered the molecular target. Curcumin is the main ingredient of Curcuma longa (turmeric) that has been used in traditional medicine for treating several diseases for years. Numerous investigations have indicated the beneficial effect of Curcumin in modulating multiple signaling pathways involved in oxidative stress, inflammation, apoptosis, and proliferation. The cardiovascular protective effects of Curcumin against CVDs have been indicated in several studies. In the current review study, we provided novel information on Curcumin's protective effects against various CVDs and potential molecular signaling targets of Curcumin. Nonetheless, more studies should be performed to discover the exact molecular target of Curcumin against CVDs.

Study Type : Review

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