Abstract Title:

Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs.

Abstract Source:

Biol Pharm Bull. 2003 Jul;26(7):1021-4. PMID: 12843631

Abstract Author(s):

Arjun Ram, Moumita Das, Balaram Ghosh

Article Affiliation:

Molecular Immunology and Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Delhi University Campus, India.


Anti-asthmatic property of curcumin (diferuloylmethane), a natural product from the rhizomes of Curcuma longa, has been tested in a guinea pig model of airway hyperresponsiveness. We sensitized guinea pigs with ovalbumin (OVA) to develop certain characteristic features of asthma: allergen induced airway constriction and airway hyperreactivity to histamine. Guinea pigs were treated with curcumin during sensitization (to examine its preventive effect) or after developing impaired airways features (to examine its therapeutic effect). Status of airway constriction and airway hyperreactivity were determined by measuring specific airway conductance (SGaw) using a non-invasive technique, constant-volume body plethysmography. Curcumin (20 mg/kg body weight) treatment significantly inhibits OVA-induced airway constriction (p<0.0399) and airway hyperreactivity (p<0.0043). The results demonstrate that curcumin is effective in improving the impaired airways features in the OVA-sensitized guinea pigs.

Study Type : Animal Study

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