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Article Publish Status: FREE
Abstract Title:

Curcumin Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm by Inhibition of Inflammatory Response and ERK Signaling Pathways.

Abstract Source:

Evid Based Complement Alternat Med. 2014 ;2014:270930. Epub 2014 Nov 6. PMID: 25431606

Abstract Author(s):

QingQing Hao, Xu Chen, XiaoYu Wang, Bo Dong, ChuanHua Yang

Article Affiliation:

QingQing Hao

Abstract:

Background and Objectives. Curcumin has long been used to treat age-related diseases, such as atherosclerosis and coronary heart disease. In this study, we explored the effects of curcumin on the development of abdominal aortic aneurysm (AAA). Methods. ApoE(-/-) mice were randomly divided into 3 groups: AngII group, AngII + curcumin (AngII + Cur) group (100 mg/kg/d), and the control group. Miniosmotic pumps were implanted subcutaneously in ApoE(-/-) mice to deliver AngII for 28 days. After 4-week treatment, abdominal aortas with AAA were obtained for H&E staining, immunohistochemistry, and Western blotting. Results. The results showed that curcumin treatment significantly decreased the occurrence of AAA. The levels of macrophage infiltration, monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factors-α (TNF-α) were significantly lower in AngII + Cur group than those in AngII group (all P<0.01). The level of superoxide dismutase (SOD) was significantly higher in AngII + Cur group than those in AngII group (P<0.01). The ERK1/2 phosphorylation in AngII + Cur group was significantly lower than that in AngII group (P<0.01). Conclusions. These results suggested that curcumin can inhibit the AngII-induced AAA in ApoE(-/-) mice, whose mechanisms include the curcumin anti-inflammation, antioxidative stress, and downregulation of ERK signaling pathway.

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