Article Publish Status: FREE
Abstract Title:

Curcumin augments the cytostatic and anti-invasive effects of mitoxantrone on carcinosarcoma cells in vitro.

Abstract Source:

Acta Biochim Pol. 2016 Jul 8. Epub 2016 Jul 8. PMID: 27390785

Abstract Author(s):

Marcin Luty, Edyta Kwiecień, Magdalena Firlej, Anna Łabędź-Masłowska, Milena Paw, Zbigniew Madeja, Jarosław Czyż

Article Affiliation:

Marcin Luty


Numerous adverse effects limit the applicability of mitoxantrone for the treatment of drug-resistant tumors, including carcinosarcoma. Here, we estimated the additive effects of mitoxantrone and curcumin, a plant-derived biomolecule isolated from Curcuma longa, on the neoplastic and invasive potential of carcinosarcoma cells in vitro. Curcumin augmented the cytostatic, cytotoxic and anti-invasive effects of mitoxantrone on the Walker-256 cells. It also strengthened the inhibitory effects of mitoxantrone on the motility of drug-resistant Walker-256 cells that had retained viability after a long-term mitoxantrone/curcumin treatment. Thus, curcumin reduces the effective doses of mitoxantrone and augments its interference with the invasive potential of drug-resistant carcinosarcoma cells.

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