Article Publish Status: FREE
Abstract Title:

Curcumin inhibits proliferation of interleukin-22-treated HaCaT cells.

Abstract Source:

Int J Clin Exp Med. 2015;8(6):9580-9584. Epub 2015 Jun 15. PMID: 26309628

Abstract Author(s):

Yi Zhao, Jun Sun, Wei Dou, Jin-Hong Hu

Article Affiliation:

Yi Zhao

Abstract:

The interleukin (IL)-23/IL-17A/IL-22 cytokine axis plays a critical role in the pathogenesis of psoriasis, wherein IL-22 effects on epidermal alternations by inhibiting differentiation and inducing keratinocyte proliferation. In this study, we investigated effects of curcumin on IL-22-induced proliferation in a human keratinocyte cell line (HaCaT) in vitro experiment. The HaCaT cells growth was measured by a Cell Counting Kit-8. The cyclin D1 and cyclin E was detected by real-time RT-PCR and weatern blot. The STAT3 and phosphorylation of STAT3 was tested by weatern blot also. Our results show that curcumin exhibited a significant anti-proliferation effect on HaCaT cells, even in the presence of IL-22. Since STAT3 is crucial for IL-22 signal transduction, we examined the level of phosphorylation of STAT3 in all of the experimental groups. As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment. Therefore, we have confidence in future curcumin research about psoriasis treatment.

Study Type : Human In Vitro
Additional Links
Pharmacological Actions : Antiproliferative : CK(6801) : AC(5032)

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