Abstract Title:

Increase of therapeutic activity of doxorubicin by long circulating liposomes in combination with curcumin.

Abstract Source:

Pharmazie. 2011 Nov ;66(11):871-4. PMID: 22204133

Abstract Author(s):

Hong Wang, Liandong Hu, Chunlei Li, Jingguo Zhang, Tao Zhang

Article Affiliation:

Hebei Medical University, Baoding, Hebei Province, P. R. China. [email protected]


In this study, doxorubicin (DOX)-loaded long circulating liposomes combined with curcumin (CUR) (DOX-CUR-LCLs) were successfully prepared as a novel formulation for cancer treatment. The particle size and distribution, zeta potential, drug loading capacity, and entrapment efficiency (EE) of the preparation were characterized. The in vitro anti-tumor activities of DOX-CUR-LCLs and DOX-LCLs against A549 cells were then evaluated and compared with that of free DOX. Cytotoxicity evaluation showed that DOX-CUR-LCLs had a significantly higher antitumor activity than other DOX preparations. These results suggest that novel DOX-CUR-LCLs, combination of DOX and CUR administered in long-circulating liposomes, could improve antitumor activity.

Study Type : In Vitro Study

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