Abstract Title:

Induction of apoptotic death by curcumin in human tongue squamous cell carcinoma SCC-4 cells is mediated through endoplasmic reticulum stress and mitochondria-dependent pathways.

Abstract Source:

Cell Biochem Funct. 2011 Sep 1. Epub 2011 Sep 1. PMID: 21887696

Abstract Author(s):

Siu-Wan Ip, Shan-Ying Wu, Chien-Chih Yu, Chao-Lin Kuo, Chun-Shu Yu, Jai-Sing Yang, Zen-Pin Lin, Shang-Ming Chiou, Hsiung-Kwang Chung, Heng-Chien Ho, Jing-Gung Chung

Article Affiliation:

Department of Nutrition, China Medical University, Taichung, Taiwan.


Curcumin from the rhizome of the Curcuma longa plant has been noted for its chemo-preventative and chemo-therapy activities, and it inhibits the growth of many types of human cancer cell lines. In this study, the mechanisms of cell death involved in curcumin-induced growth inhibition, including cell cycle arrest and induction of apoptosis in human tongue cancer SCC-4 cells, were investigated. Herein, we observed that curcumin inhibited cell growth of SCC-4 cells and induced cell death in a dose-dependent manner. Treatment of SCC-4 cells with curcumin caused a moderate and promoted the G(2) /M phase arrest, which was accompanied with decreases in cyclin B/CDK1 and CDC25C protein levels. Moreover, curcumin significantly induced apoptosis of SCC-4 cells with a decrease of the Bcl-2 level, reduction of mitochondrial membrane potential (ΔΨ(m) ), and promoted the active forms of caspase-3. Curcumin also promoted the releases of AIF and Endo G from the mitochondria in SCC-4 cells by using confocal laser microscope. Therefore, we suggest that curcumin induced apoptosis through a mitochondria-dependent pathway in SCC-4 cells. In addition, we also found that curcumin-induced apoptosis of SCC-4 cells was partly through endoplasmic reticulum stress. In conclusion, curcumin increased G(2) /M phase arrest and induced apoptosis through ER stress and mitochondria-dependent pathways in SCC-4 cells. Copyright © 2011 John Wiley&Sons, Ltd.

Study Type : In Vitro Study

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