Curcumin has asymmetrical effects on cancer and normal stem cells. - GreenMedInfo Summary
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Article Publish Status: FREE
Abstract Title:
Curcumin and cancer stem cells: curcumin has asymmetrical effects on cancer and normal stem cells.
Abstract Source:
Anticancer Res. 2015 Feb ;35(2):599-614. PMID: 25667437
Article Affiliation:
Peter P Sordillo
Abstract:
Curcumin has been shown to have numerous cytotoxic effects on cancer stem cells (CSCs). This is due to its suppression of the release of cytokines, particularly interleukin (IL)-6, IL-8 and IL-1, which stimulate CSCs, and also to its effects at multiple sites along CSC pathways, such as Wnt, Notch, Hedgehog and FAK. In spite of its multiple actions targeting CSCs, curcumin has little toxicity against normal stem cells (NSCs). This may be due to curcumin's different effects on CSCs and NSCs.
Article Published Date : Jan 31, 2015
Study Type : Review
Additional Links
Substances : Curcumin : CK(6902) : AC(3212)
Diseases : Cancers: All : CK(34182) : AC(14047)
Pharmacological Actions : Interleukin-6 Downregulation : CK(9048) : AC(3503)
Additional Keywords : Cancer Stem Cells : CK(492) : AC(363), Selective Cytotoxicity : CK(269) : AC(200)
