Abstract Title:

Antitumor activity of curcumin is mediated through the induction of apoptosis in AK-5 tumor cells.

Abstract Source:

FEBS Lett. 1999 Feb 19;445(1):165-8. PMID: 10069393

Abstract Author(s):

A Khar, A M Ali, B V Pardhasaradhi, Z Begum, R Anjum

Article Affiliation:

Centre for Cellular and Molecular Biology, Hyderabad, India. [email protected]

Abstract:

Curcumin, the yellow pigment of turmeric (Curcuma longa), used commonly as a spice, has been shown to possess anticarcinogenic activity. Curcumin inhibited AK-5 tumor growth and induced apoptosis in AK-5 cells. Curcumin induced apoptosis is mediated through the activation of caspase-3, which is specifically inhibited by the tetrapeptide Ac-DEVD-CHO. In addition, curcumin induced tumor cell death is caused through the generation of reactive oxygen intermediates which is inhibited by N-acetyl-L-cysteine. Our studies suggest that the apoptotic process induced by curcumin is the mechanism mediating AK-5 tumor cell death.

Study Type : In Vitro Study

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