Abstract Title:

Curcumin inhibits Jurkat cell proliferation by inducing apoptosis via activation-induced cell death.

Abstract Source:

Trends Endocrinol Metab. 2009 Apr;20(3):139-45. Epub 2009 Mar 9. PMID: 20863651

Abstract Author(s):

V S Yadav, K P Mishra, D P Singh

Article Affiliation:

Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India.


The effects of curcumin on cell proliferation, activation-induced cell death (AICD) and expression of interleukin-2 (IL-2) receptors (IL-2Rα, CD25) by Jurkat cells were investigated. Incubation of Jurkat cells for 72h with either phytohaemagglutinin (PHA) or curcumin (2.5μg/mL) resulted in marked inhibition of cell proliferation, determined by (3)H-thymidine incorporation. The anticancer activity of curcumin was also confirmed by quantitating the PHA-induced AICD in Jurkat cells by flow cytometry. It was found that curcumin (2.5μg/mL) enhanced apoptosis in PHA-treated Jurkat cells. Further we observed the level of CD25 expression on Jurkat cells by flow cytometry. Our data indicate that curcumin inhibited PHA-induced CD25 expression. The present study suggests that curcumin have potent anticancer activities, which might be useful in lymphoma treatment.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(6986) : AC(5304)

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.